Interaction of E1040 with cephalosporinase from Citrobacter freundii GN7391

Author:

Inoue E1,Mitsuhashi S1

Affiliation:

1. Episome Institute, Gunma, Japan.

Abstract

The interactions of E1040 with cephalosporinase from Citrobacter freundii, including affinity and hydrolysis, were studied in comparison with those of cefotaxime and ceftazidime. E1040 showed a higher stability at low drug concentrations and a much lower affinity for the enzyme than did cefotaxime or ceftazidime. These enzymological properties explain the high activity of E1040 against cephalosporinase-producing C. freundii.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Decreased Production of AmpC-Type β-Lactamases Associated with the Development of Resistance to Quinolones inCitrobacter freundiiStrains;Microbial Drug Resistance;1999-01

2. New concepts in the field of cephalosporins: C-3' quaternary ammonium cephems (Group IV);Clinical Microbiology and Infection;1997-04

3. Annotated References;Expert Opinion on Investigational Drugs;1994-02

4. Parenteral cephalosporin classification;Expert Opinion on Investigational Drugs;1994-02

5. In vitro and in vivo activities of DQ-2556 and its mode of action;Antimicrobial Agents and Chemotherapy;1992-12

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3