Synthesis of type 2 Adenovirus DNA in the Presence of Cycloheximide

Author:

Horwitz Marshall S.1,Brayton Carol1,Baum Stephen G.1

Affiliation:

1. Departments of Microbiology and Immunology, Pediatrics, Cell Biology, and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461

Abstract

Adenovirus type 2 DNA synthesis, either in permissive human cells or nonpermissive monkey cells, becomes independent of protein synthesis after the appearance of progeny viral DNA. In the presence of cycloheximide, semiconservative replication and initiation of progeny molecules can occur.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference24 articles.

1. Studies of the mechanism of enhancement of human adenovirus infection in monkey cells by simian virus 40;Baum S. G.;J. Virol.,1972

2. Inhibition of DNA synthesis in mammalian cells by;Bennett L. L.;Actidione. Biochim. Biophys. Acta,1964

3. Induction of excessive deoxyribonucleic acid synthesis in Escherichia coli by nalidixic acid;Boyle J. V.;J. Bacteriol.,1967

4. The effect of cycloheximide on DNA synthesis in cells productively-infected with polyoma virus;Branton P. E.;Virology,1970

5. Effect of inhibitors of protein synthesis on DNA formation in liver;Brown R. F.;Biochim. Biophys. Acta,1970

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