Both Expansion of Regulatory GR1 + CD11b + Myeloid Cells and Anergy of T Lymphocytes Participate in Hyporesponsiveness of the Lung-Associated Immune System during Acute Toxoplasmosis-Reference-Cited by-同舟云学术

Both Expansion of Regulatory GR1 + CD11b + Myeloid Cells and Anergy of T Lymphocytes Participate in Hyporesponsiveness of the Lung-Associated Immune System during Acute Toxoplasmosis

Published:2004-09 Issue:9 Volume:72 Page:5487-5492
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Voisin Mathieu-Benoît¹,Buzoni-Gatel Dominique²,Bout Daniel¹,Velge-Roussel Florence¹

Affiliation:

1. UMR Université-INRA d'Immunologie Parasitaire et Vaccinologie, UFR des Sciences Pharmaceutiques, Tours

2. Unité Réponse Précoce aux Parasites et Immunopathologie, Institut Pasteur/Institut National de la Recherche Agronomique, Paris, France

Abstract

ABSTRACT Oral infection with Toxoplasma gondii leads to transient systemic hyporesponsiveness. In this report, we characterized the presence in the lungs of GR1 + CD11b + myeloid cells that have potent nitric oxide-dependent immunoregulatory properties. We also demonstrated the interleukin 2-reversible anergy of both pulmonary CD8 + and CD4 + activated T lymphocytes with infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.9.5487-5492.2004

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