Bordetella pertussis Adenylate Cyclase-Hemolysin Induces Interleukin-6 Secretion by Human Tracheal Epithelial Cells-Reference-Cited by-同舟云学术

Bordetella pertussis Adenylate Cyclase-Hemolysin Induces Interleukin-6 Secretion by Human Tracheal Epithelial Cells

Published:2004-09 Issue:9 Volume:72 Page:5530-5533
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bassinet Laurence¹²,Fitting Catherine³,Housset Bruno²,Cavaillon Jean-Marc³,Guiso Nicole¹

Affiliation:

1. Unité Prévention et Thérapie Moléculaires des Maladies Humaines

2. Centre Hospitalier Intercommunal Créteil, Service de Pneumologie, Creteil, France

3. Unité Postulante Cytokines & Inflammation, Institut PasteurParis

Abstract

ABSTRACT After interaction with tracheal epithelial cells, Bordetella pertussis induces the secretion of interleukin-6. This secretion is dependent on the expression of adenylate cyclase-hemolysin by the bacterium but not on the expression of other characterized bacterial toxins or adhesins. This finding confirms the important role of adenylate cyclase-hemolysin in the pathogenicity of the bacterium.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.9.5530-5533.2004

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