Pharmacokinetics/Pharmacodynamics of Caspofungin in Plasma and Peritoneal Fluid of Liver Transplant Recipients

Author:

Pressiat Claire1,Ait-Ammar Nawel23,Daniel Matthieu4,Hulin Anne15,Botterel Françoise23,Levesque Eric24ORCID

Affiliation:

1. Pharmacology Unit, AP-HP, Henri Mondor Hospital, Créteil, France

2. Université Paris-Est Creteil, EnvA, DYNAMiC, Faculté de Santé de Créteil, Creteil, France

3. Parasitology and Mycology Unit, Department of Prevention, Diagnosis, and Treatment of Infections, AP-HP, Henri Mondor Hospital, Créteil, France

4. Department of Anaesthesia and Surgical Intensive Care, Liver Intensive Care Unit, AP-HP, Henri Mondor Hospital, Créteil, France

5. EA 7375, EC2M3, Oncomix, Université Paris-Est Créteil, Faculté de Santé de Créteil, Institut Pasteur, Paris, France

Abstract

The weaker diffusion of echinocandins in the peritoneal fluid (PF) could promote Candida -resistant isolates. The aim of this study was to analyze the pharmacokinetics (PK)/pharmacodynamics (PD) of caspofungin in plasma and PF samples from liver transplant recipients.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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