Association between Polymorphisms in the Pf mdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal-Reference-Cited by-同舟云学术

Association between Polymorphisms in the Pf mdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal

Published:2017-03 Issue:3 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gendrot Mathieu¹²,Diawara Silman³,Madamet Marylin²⁴⁵,Kounta Mame Bou⁶,Briolant Sébastien¹²⁷⁸,Wade Khalifa Ababacar⁶,Fall Mansour⁹,Benoit Nicolas²⁴⁵,Nakoulima Aminata¹⁰,Amalvict Rémy²⁴⁵,Diémé Yaya³,Fall Bécaye³,Wade Boubacar¹¹,Diatta Bakary⁹¹¹,Pradines Bruno¹²³⁵

Affiliation:

1. Unité de Parasitologie et d'Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France

2. Aix Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France

3. Laboratoire d'étude de la chimiosensibilité du paludisme, Fédération des laboratoires, Hôpital Principal de Dakar, Dakar, Senegal

4. Equipe résidente de recherche en infectiologie tropicale, Institut de Recherche Biomédicale des Armées, Hôpital d'instruction des armées, Marseille, France

5. Centre national de référence du Paludisme, Marseille, France

6. Service des Urgences, Hôpital Principal de Dakar, Dakar, Senegal

7. Direction Interarmées du Service de Santé, Cayenne, Guyane, France

8. Laboratoire de Parasitologie, Institut Pasteur de la Guyane, Cayenne, Guyane, France

9. Service de Réanimation Médicale, Hôpital Principal de Dakar, Dakar, Senegal

10. Service de Pédiatrie, Hôpital Principal de Dakar, Dakar, Senegal

11. Chefferie, Hôpital Principal de Dakar, Dakar, Senegal

Abstract

ABSTRACT Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese Plasmodium falciparum isolates to evaluate the association between the number of Asn residues in the polymorphic microsatellite region of the Plasmodium falciparum multidrug resistance 6 gene (Pf mdr6 ) and the ex vivo susceptibility to antimalarials. A significant association was observed between the presence of 7 or 9 Asn repeats and reduced susceptibility to quinine.

Funder

Schéma Directeur Paludisme, Etat major des armées

Ministère des Affaires Etrangéres

Délégation Générale pour l'Armement

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01183-16

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