Effect of Sub-MICs of Macrolides on the Sensitivity of Pseudomonas aeruginosa to Nitrosative Stress: Effectiveness against P. aeruginosa with and without Multidrug Resistance-Reference-Cited by-同舟云学术

Effect of Sub-MICs of Macrolides on the Sensitivity of Pseudomonas aeruginosa to Nitrosative Stress: Effectiveness against P. aeruginosa with and without Multidrug Resistance

Published:2020-09-21 Issue:10 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Shimizu Takeshi¹^ORCID,Miyoshi-Akiyama Tohru²,Ogura Kohei³,Murata Shota⁴,Ishige Shota¹,Kai Kiyohiro¹,Mitsutsuka Konosuke¹,Tomita Haruyoshi⁵⁶,Tanimoto Koichi⁶,Matsumoto Akio⁷

Affiliation:

1. Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan

2. Pathogenic Microbe Laboratory, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

3. Advanced Health Care Science Research Unit, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Ishikawa, Japan

4. Division of Laboratory Medicine, Chiba University Hospital, Chiba, Japan

5. Department of Bacteriology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan

6. Laboratory of Bacterial Drug Resistance, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan

7. Department of Aging Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan

Abstract

Sub-MICs of the 14-membered macrolides erythromycin (EM) and clarithromycin (CAM) decreased the growth of Pseudomonas aeruginosa PAO1 and increased its sensitivity to endogenous and exogenous nitrosative stress. However, a 16-membered macrolide, josamycin (JM), was not or less effective. In 9 of 13 non-multidrug-resistant P. aeruginosa (non-MDRP) and 9 of 27 MDRP ST235 strains, the sub-MIC of EM induced significant reductions in bacterial numbers following treatment with a nitric oxide donor.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01180-20

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