"The end of innocence" revisited: resistance of herpesviruses to antiviral drugs

Author:

Field A K1,Biron K K1

Affiliation:

1. Hybridon, Inc., Worcester, Massachusetts 01605.

Abstract

In the past 4 years, interest in drug-resistant herpesviruses has evolved from the realm of academic laboratory studies to that of great clinical importance. Recurrent and persistent infections due to the herpes simplex viruses, varicella-zoster virus, and human cytomegalovirus have been an unwelcome consequence of immunosuppression in graft recipients, cancer patients, and those suffering from AIDS. Treatment of these infections with the available antiviral drugs, such as acyclovir, ganciclovir, and foscarnet, has resulted in both clinical benefit and the emergence of drug-resistant variants. In addition, the role of Epstein-Barr virus is being clarified for an array of disease syndromes, and therapeutic approaches are beginning to emerge. In the present review, the emergence and clinical importance of drug resistance among the herpesviruses have been explored. Furthermore, particular attention has been focused on our understanding of the mechanisms of drug resistance and how that understanding will guide us in the development of more effective antiviral drugs and drug usage.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Reference147 articles.

1. Severe and recurrent varicella-zoster virus infection in a patient with the acquired immune deficiency syndrome;Acheson D. W. K.;J. Infect.,1988

2. Unusual varicella zoster virus infection in patients with the acquired immunodeficiency syndrome;Alessi E.;Arch. Dermatol.,1988

3. Balfour H. H. Jr. 1988. Varicella zoster virus infections in immunocompromised hosts. A review of the natural history and management. Am. J. Med. 85(Suppl. 2A):68-73.

4. Varicella zoster virus infections in the immunocompromised host. Natural history and treatment;Balfour H. H.;Scand. J. Infect. Dis. Suppl.,1991

5. A randomized, placebocontrolled trial of oral acyclovir for the prevention of cytomegalovirus disease in recipients of renal allografts;Balfour H. H.;N. Engl. J. Med.,1989

Cited by 139 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3