Novel Mutations in ndh in Isoniazid-Resistant Mycobacterium tuberculosis Isolates-Reference-Cited by-同舟云学术

Novel Mutations in ndh in Isoniazid-Resistant Mycobacterium tuberculosis Isolates

Published:2001-07 Issue:7 Volume:45 Page:2157-2159
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lee Ann S. G.¹²,Teo Audrey S. M.³,Wong Sin-Yew³

Affiliation:

1. Department of Clinical Research, Singapore General Hospital, Singapore 169608,1

2. Division of Medical Sciences, National Cancer Centre, Singapore 169610,2 and

3. Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore 308433,3 Singapore

Abstract

ABSTRACT Novel mutations in NADH dehydrogenase ( ndh ) were detected in 8 of 84 (9.5%) isoniazid (INH)-resistant isolates (T110A [ n = 1], R268H [ n = 7]), but not in 22 INH-susceptible isolates of Mycobacterium tuberculosis . Significantly, all eight isolates with mutations at ndh did not have mutations at katG, kasA , or the promoter regions of inhA or ahpC , except for one isolate. Mutations in ndh appear to be an additional molecular mechanism for isoniazid resistance in M. tuberculosis .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.7.2157-2159.2001

Reference18 articles.

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3. Contribution of kasA Analysis to Detection of Isoniazid-Resistant Mycobacterium tuberculosis in Singapore

4. Lack of clinical significance for the common arginine-to-leucine substitution at codon 463 of the katG gene in isoniazid-resistant Mycobacterium tuberculosis in Singapore.;Lee A. S. G.;J. Infect. Dis.,1997

5. Purification and characterization of the Mycobacterium smegmatis catalase-peroxidase involved in isoniazid activation.;Marcinkeviciene J. A.;J. Biol. Chem.,1995

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