Structural Diversity of Streptokinase and Activation of Human Plasminogen-Reference-Cited by-同舟云学术

Structural Diversity of Streptokinase and Activation of Human Plasminogen

Published:2005-07 Issue:7 Volume:73 Page:4451-4453
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lizano Sergio¹,Johnston Kenneth H.²

Affiliation:

1. Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595

2. Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, Louisiana 70112

Abstract

ABSTRACT The β domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.7.4451-4453.2005

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5. Natural Selection and Evolution of Streptococcal Virulence Genes Involved in Tissue-Specific Adaptations

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