Author:
Mettler N E,Clarke D H,Casals J
Abstract
Ehrlich ascitic carcinoma, as developed in albino mice, has been used as a source of hemagglutinating and complement-fixing antigens, and it proved to be suitable for one type of antigen, or both, for at least 12 viruses of 16 tested. Hemagglutinins were obtained with members of arbovirus groups A, B, and C; complement-fixing antigens were obtained for at least one member of each antigenic group tested. Ehrlich ascitic tumor was compared with sarcoma 180 as a source of antigens; although sarcoma 180 showed many advantages over Ehrlich tumor, the latter gave, in general, better results for complement-fixing antigens. Oncolytic effect with complete recovery of the mice was observed in some instances. The highest recovery rate resulted with Congo and UNA viruses (40%), and the second highest rate resulted with dengue 2, St. Louis, Hazara, and Uukuniemi viruses (20%). The best survival was observed, in decreasing order, with Congo, St. Louis, dengue 2, Tacaribe, Sindbis, Junin, and Amapari viruses.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference10 articles.
1. Berge T. 0. 1975. International catalogue of arboviruses including certain other viruses of vertebrates 2nd ed. Department of Health Education and Welfare publication no. (CDC) 75-8301. Department of Health Education and Welfare Washington D.C.
2. Casals J. 1967. Methods Virol. 3:113.
3. Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses;Clarke D. H.;Am. J. Trop. Med. Hyg.,1958
4. Ascites tumors as culture media in quantitative growth studies of viral agents;Koprowski H.;Ann. N. Y. Acad. Sci.,1956
5. Li J. C. R. 1964. In E. Brothers (ed.) Statistical inference vol. 1 p. 4-19. Ann Arbor Mich.
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献