Hyperosmotic Stress Induces Unconventional Autophagy Independent of the Ulk1 Complex-Reference-Cited by-同舟云学术

Hyperosmotic Stress Induces Unconventional Autophagy Independent of the Ulk1 Complex

Published:2019-08-15 Issue:16 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Tamura Naoki¹,Kageyama Shun²,Komatsu Masaaki²³,Waguri Satoshi¹^ORCID

Affiliation:

1. Department of Anatomy and Histology, Fukushima Medical University School of Medicine, Fukushima, Japan

2. Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

3. Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan

Abstract

Autophagy is considered an adaptive mechanism against hyperosmotic stress. Although the process has been reported to be triggered by the inhibition of mTORC1, the precise downstream mechanisms remain elusive. Here, we demonstrate that hyperosmotic-stress-induced autophagy is different from conventional macroautophagy in mouse embryonic fibroblasts (MEFs) and human T24 cells.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00024-19

Reference43 articles.

1. Cellular Response to Hyperosmotic Stresses

2. Physiology of Cell Volume Regulation in Vertebrates

3. Patterns of duodenal osmolality in young pigs fed solid food