Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex-Reference-Cited by-同舟云学术

Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex

Published:2019-07 Issue:13 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

McClellan David¹,Casey Mattie J.¹,Bareyan Diana¹,Lucente Helena¹,Ours Christopher²³,Velinder Matthew⁴,Singer Jason⁴,Lone Mehraju Din¹,Sun Wenxiang¹,Coria Yunuen¹,Mason Clinton C.²³,Engel Michael E.¹²³⁵⁶

Affiliation:

1. Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah, USA

2. Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA

3. Primary Children’s Hospital, Salt Lake City, Utah, USA

4. Department of Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA

5. Center for Investigational Therapeutics, Huntsman Cancer Institute, Salt Lake City, Utah, USA

6. Nuclear Control of Cell Growth and Differentiation Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA

Abstract

Growth factor independence 1B (GFI1B) coordinates assembly of transcriptional repressor complexes comprised of corepressors and histone-modifying enzymes to control gene expression programs governing lineage allocation in hematopoiesis. Enforced expression of GFI1B in K562 erythroleukemia cells favors erythroid over megakaryocytic differentiation, providing a platform to define molecular determinants of binary fate decisions triggered by GFI1B.

Funder

HHS | National Institutes of Health

American Cancer Society

Alex's Lemonade Stand Foundation for Childhood Cancer

Hyundai Motor Group | Hyundai Motor America | Hyundai Hope On Wheels

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00020-19

Reference99 articles.