High-pressure liquid chromatography analysis of antibiotic susceptibility disks-Reference-Cited by-同舟云学术

High-pressure liquid chromatography analysis of antibiotic susceptibility disks

Published:1979-09 Issue:3 Volume:16 Page:372-377
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hagel R B,Waysek E H,Cort W M

Abstract

The analysis of antibiotic susceptibility disks by high-pressure liquid chromatography (HPLC) was investigated. Methods are presented for the potency determination of mecillinam, ampicillin, carbenicillin, and cephalothin alone and in various combinations. Good agreement between HPLC and microbiological data is observed for potency determinations with recoveries of greater than 95%. Relative standard deviations of lower than 2% are recorded for each HPLC method. HPLC methods offer improved accuracy and greater precision when compared to the standard microbiological methods of analysis for susceptibility disks.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.16.3.372

Reference13 articles.

1. Carbenicillin: chemistry and mode of action;Butler K.;J. Infect. Dis.,1979

2. Code of Federal Regulations 1978.21 CFR 460.6. Tests and methods of assay for the potency of antibiotic susceptibility discs 740-747. U. S. Government Washington D. C.

3. Code of Federal Regulations. 1978. 21 CFR 460.15(f). Tests and methods of assay for the potency of antibiotic susceptibility discs p. 747. U. S. Government Washington D. C.

4. Code of Federal Regulations. 1978. 21 CFR 460.28. Disodium carbenicillin diagnostic sensitivity powder p. 749-750. U. S. Government Washington D. C.

5. Rapid determination of serum 5-fluorocytosine levels by high-presure liquid chromatography;Diasio R. B.;Antimicrob. Agents Chemother.,1978

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