Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner-Reference-Cited by-同舟云学术

Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner

Published:2019-06-15 Issue:12 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Shakya Akhalesh K.¹²,O’Callaghan Dennis J.¹²,Kim Seong K.¹²

Affiliation:

1. Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA

2. Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA

Abstract

Our results showed that IFN-γ significantly inhibited VZV replication in a cell line-dependent manner. IFN-γ inhibited VZV gene expression after the immediate early stage of infection and abrogated IE62-mediated transactivation. These results suggest that IFN-γ blocks VZV replication by inhibiting IE62 function in a cell line-dependent manner. Understanding the mechanisms by which IFN-γ plays a role in VZV gene programming may be important in determining the tissue restriction of VZV.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00257-19

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