Linking the Salmonella enterica 1,2-Propanediol Utilization Bacterial Microcompartment Shell to the Enzymatic Core via the Shell Protein PduB

Author:

Kennedy Nolan W.1ORCID,Mills Carolyn E.2ORCID,Abrahamson Charlotte H.2ORCID,Archer Andre G.3,Shirman Sasha3ORCID,Jewett Michael C.24ORCID,Mangan Niall M.34ORCID,Tullman-Ercek Danielle24ORCID

Affiliation:

1. Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois, USA

2. Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA

3. Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois, USA

4. Center for Synthetic Biology, Northwestern University, Evanston, Illinois, USA

Abstract

MCPs are unique, genetically encoded organelles used by many bacteria to survive in resource-limited environments. There is significant interest in understanding the biogenesis and function of these organelles, both as potential antibiotic targets in enteric pathogens and also as useful tools for overcoming metabolic engineering bottlenecks.

Funder

DOD | US Army | RDECOM | Army Research Office

HHS | National Institutes of Health

National Science Foundation

U.S. Department of Energy

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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