Survey of Antimicrobial Resistance in Clinical Burkholderia pseudomallei Isolates over Two Decades in Northeast Thailand

Author:

Wuthiekanun Vanaporn1,Amornchai Premjit1,Saiprom Natnaree2,Chantratita Narisara12,Chierakul Wirongrong13,Koh Gavin C. K. W.14,Chaowagul Wipada5,Day Nicholas P. J.16,Limmathurotsakul Direk17,Peacock Sharon J.124

Affiliation:

1. Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand

2. Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand

3. Department of Clinical Tropical Medicine, Mahidol University, Bangkok, Thailand

4. Department of Medicine, Cambridge University, Addenbrooke's Hospital, Cambridge, United Kingdom

5. Department of Medicine, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand

6. Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom

7. Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Abstract

ABSTRACT A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant to ceftazidime ( n = 8), amoxicillin-clavulanic acid ( n = 4), or both drugs ( n = 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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