Function of the MYND Domain and C-Terminal Region in Regulating the Subcellular Localization and Catalytic Activity of the SMYD Family Lysine Methyltransferase Set5-Reference-Cited by-同舟云学术

Function of the MYND Domain and C-Terminal Region in Regulating the Subcellular Localization and Catalytic Activity of the SMYD Family Lysine Methyltransferase Set5

Published:2020-01-03 Issue:2 Volume:40 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Jaiswal Deepika¹,Turniansky Rashi¹,Moresco James J.²,Ikram Sabeen¹,Ramaprasad Ganesh¹,Akinwole Assefa¹,Wolf Julie¹,Yates John R.²,Green Erin M.¹

Affiliation:

1. Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland, USA

2. Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA

Abstract

SMYD lysine methyltransferases target histones and nonhistone proteins for methylation and are critical regulators of muscle development and implicated in neoplastic transformation. They are characterized by a split catalytic SET domain and an intervening MYND zinc finger domain, as well as an extended C-terminal domain. Saccharomyces cerevisiae contains two SMYD proteins, Set5 and Set6, which share structural elements with the mammalian SMYD enzymes.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00341-19

Reference70 articles.

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