Author:
Bonnin Rémy A.,Potron Anaïs,Poirel Laurent,Lecuyer Hervé,Neri Rita,Nordmann Patrice
Abstract
ABSTRACTAcinetobacter baumanniiisolate AP2 was recovered from a bronchial lavage sample of a patient hospitalized in Paris, France.A. baumanniiAP2 was resistant to all β-lactams, including carbapenems, and expressed the extended-spectrum β-lactamase (ESBL) PER-7, which differs from PER-1 by 4 amino acid substitutions. Compared to PER-1, PER-7 possessed higher-level hydrolytic activities against cephalosporins and aztreonam. TheblaPER-7gene was chromosomally located and associated with a mosaic class 1 integron structure. Additionally, isolate AP2 expressed the carbapenem-hydrolyzing oxacillinase OXA-23 and the 16S RNA methylase ArmA, conferring high-level resistance to aminoglycosides.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
55 articles.
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