Structural Domains of the Herpes Simplex Virus 1 gD Protein That Restrict Human Immunodeficiency Virus Particle Infectivity

Abstract

Previously, we showed that unlike HSV-1, the presence of the gD glycoprotein in virus producer cells but not gB potently restricted HIV-1 particle infectivity. To better understand the relationship between cell surface expression, virus incorporation, and restriction of HIV-1, we analyzed a series of deletion mutants and chimeric proteins in which domains of gD and gB were swapped.