Abstract
In the absence of egg antigen (SEA), spleen cells from C57BL/6 mice infected for 22 weeks with Schistosoma japonicum were spontaneously induced in vitro to synthesize total immunoglobulin and antibody to SEA. Hepatic granulomas from mice infected for 12 weeks, but not for 22 weeks, also showed spontaneous syntheses of total immunoglobulin and antibody to SEA, but these syntheses were not enhanced upon the addition of SEA. Total immunoglobulin production was enhanced when SEA was added to spleen cells from mice infected for 4 to 7 weeks but not at any other time point.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference8 articles.
1. Differential requirements for antigen processing by macrophages for Iysozyme-specific T cell hybridomas;Allen P. M.;J. Immunol.,1984
2. Delayed hypersensitivity type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs;Boros D. L.;J. Exp. Med.,1970
3. Depressed in vitro and in vivo antibody response and adoptive transfer of delayed hypersensitivity to myoglobin with spleen cells of mice chronically infected with Schistosoma japonicum and injected with myoglobin;Garb K. S.;Infect. Immun.,1984
4. Dynamics of antigen and mitogen-induced responses in murine schistosomiasis japonica: in vitro comparison between hepatic granulomas and splenic cells;Garb K. S.;J. Immunol.,1981
5. Immune regulation in murine schistosomiasis japonica: inhibition of in vitro antigen- and mitogeninduced cellular responses by splenocyte culture supernatants and by purified fractions from serum of chronically infected mice;Garb K. S.;J. Immunol.,1982
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献