A Putative Amphipathic Alpha Helix in Hepatitis B Virus Small Envelope Protein Plays a Critical Role in the Morphogenesis of Subviral Particles-Reference-Cited by-同舟云学术

A Putative Amphipathic Alpha Helix in Hepatitis B Virus Small Envelope Protein Plays a Critical Role in the Morphogenesis of Subviral Particles

Published:2021-03-25 Issue:8 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yang Sisi¹²,Shen Zhongliang¹,Kang Yaoyue¹,Sun Liren²,Viswanathan Usha²,Guo Hongying¹,Zhou Tianlun²^ORCID,Dai Xinghong³,Chang Jinhong²,Zhang Jiming¹,Guo Ju-Tao²^ORCID

Affiliation:

1. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China

2. Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA

3. Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Abstract

SVPs are the predominant viral product produced by HBV-infected hepatocytes. Their levels exceed those of virion particles by 10,000- to 100,000-fold in the blood of HBV-infected individuals.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02399-20

Reference71 articles.

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2. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound

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4. Hepatitis B Virus Virions Produced Under Nucleos(t)ide Analogue Treatment Are Mainly Not Infectious Because of Irreversible DNA Chain Termination

5. Secretion of Genome-Free Hepatitis B Virus – Single Strand Blocking Model for Virion Morphogenesis of Para-retrovirus

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