Membrane Binding of Input Arbovirus Ribonucleic Acid: Effect of Interferon or Cycloheximide-Reference-Cited by-同舟云学术

Membrane Binding of Input Arbovirus Ribonucleic Acid: Effect of Interferon or Cycloheximide

Published:1970-08 Issue:2 Volume:6 Page:169-175
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Friedman Robert M.¹²,Sreevalsan T.¹²

Affiliation:

1. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

2. Department of Microbiology, School of Medicine and Dentistry, Georgetown University, Washington, D.C. 20007

Abstract

By 1 hr after infection, 36% of input Semliki Forest virus ribonucleic acid (RNA) which was cell associated was found in a membrane structure. This structure had many similarities to the membrane-associated replication complex (MRC) which had previously been identified in arbovirus infections. Interferon treatment did not affect the association of viral RNA with the MRC structure, but cycloheximide treatment inhibited it.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.6.2.169-175.1970

Reference16 articles.

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2. Mechanism of action of interferon. I. Relationship with viral ribonucleic acid;De Somer P.;Virology,1962

3. Further purification of chick interferon;Fantes K. H.;Nature (London),1965

4. Inhibition of arbovirus protein synthesis by interferon;Friedman R. M.;J. Virol.,1968

5. Replicative intermediate of an arbovirus;Friedman R. M.;J. Virol.,1968

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