H <sub>2</sub> O <sub>2</sub> -Driven Hydroxylation of Steroids Catalyzed by Cytochrome P450 CYP105D18: Exploration of the Substrate Access Channel-Reference-Cited by-同舟云学术

H ₂ O ₂ -Driven Hydroxylation of Steroids Catalyzed by Cytochrome P450 CYP105D18: Exploration of the Substrate Access Channel

Published:2023-01-31 Issue:1 Volume:89 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Pardhe Bashu Dev¹^ORCID,Kwon Kyoung Pyo²,Park Jong Kook³,Lee Jun Hyuck⁴⁵^ORCID,Oh Tae-Jin¹²⁶^ORCID

Affiliation:

1. Department of Life Science and Biochemical Engineering, Sunmoon University, Asan-si, Chungnam, Republic of Korea

2. Department of Pharmaceutical Engineering and Biotechnology, Sunmoon University, Asan-si, Chungnam, Republic of Korea

3. Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chuncheon, Gangwon-do, Republic of Korea

4. Research Unit of Cryogenic Novel Material, Korea Polar Research Institute, Incheon, Republic of Korea

5. Department of Polar Sciences, University of Science and Technology, Incheon, Republic of Korea

6. Genome-based BioIT Convergence Institute, Asan-si, Chungnam, Republic of Korea

Abstract

The structural modification of steroids is a challenging chemical reaction. Modifying the core ring and the side chain improves the biological activity of steroids.

Funder

The National Research Foundation of Korea

The Ministry of Oceans and Fisheries, Korea

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.01585-22

Reference46 articles.

1. Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China

2. Bacterial cytochrome P450-catalyzed regio- and stereoselective steroid hydroxylation enabled by directed evolution and rational design

3. Oxidative Diversification of Steroids by Nature-Inspired Scanning Glycine Mutagenesis of P450BM3 (CYP102A1)

4. Common and Uncommon Cytochrome P450 Reactions Related to Metabolism and Chemical Toxicity

5. Formation and Cleavage of C–C Bonds by Enzymatic Oxidation–Reduction Reactions

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Analysis of critical residues for peroxygenation and improved peroxygenase activity via in situ H2O2 generation in CYP105D18;Frontiers in Microbiology;2023-12-11

2. Correction for Pardhe et al., “H ₂ O ₂ -Driven Hydroxylation of Steroids Catalyzed by Cytochrome P450 CYP105D18: Exploration of the Substrate Access Channel”;Applied and Environmental Microbiology;2023-11-29

3. Efficient regio- and stereo-selective C–H bond hydroxylation of steroids using an engineered heme-thiolate peroxygenase biocatalyst;Catalysis Science & Technology;2023