From People to Panthera : Natural SARS-CoV-2 Infection in Tigers and Lions at the Bronx Zoo-Reference-Cited by-同舟云学术

From People to Panthera : Natural SARS-CoV-2 Infection in Tigers and Lions at the Bronx Zoo

Published:2020-10-27 Issue:5 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

McAloose Denise¹^ORCID,Laverack Melissa²,Wang Leyi³,Killian Mary Lea⁴,Caserta Leonardo C.²,Yuan Fangfeng⁵,Mitchell Patrick K.²,Queen Krista⁶,Mauldin Matthew R.⁶^ORCID,Cronk Brittany D.²,Bartlett Susan L.¹,Sykes John M.¹,Zec Stephanie¹,Stokol Tracy²,Ingerman Karen¹,Delaney Martha A.⁷,Fredrickson Richard³,Ivančić Marina⁸,Jenkins-Moore Melinda⁴,Mozingo Katie⁴,Franzen Kerrie⁴,Bergeson Nichole Hines⁴,Goodman Laura²^ORCID,Wang Haibin⁶,Fang Ying⁵,Olmstead Colleen³,McCann Colleen¹,Thomas Patrick¹,Goodrich Erin²,Elvinger François²,Smith David C.⁹,Tong Suxiang⁶,Slavinski Sally¹⁰,Calle Paul P.¹,Terio Karen⁷,Torchetti Mia Kim⁴,Diel Diego G.²^ORCID

Affiliation:

1. Wildlife Conservation Society, Bronx Zoo, Bronx, New York, USA

2. Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA

3. Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA

4. National Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA), Ames, Iowa, USA

5. Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA

6. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

7. Zoological Pathology Program, College of Veterinary Medicine, University of Illinois, Brookfield, Illinois, USA

8. Chicago Zoological Society, Chicago, Illinois, USA

9. New York State Department of Agriculture and Markets, Albany, New York, USA

10. New York City Department of Health and Mental Hygiene, Queens, New York, USA

Abstract

The human-animal-environment interface of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important aspect of the coronavirus disease 2019 (COVID-19) pandemic that requires robust One Health-based investigations. Despite this, few reports describe natural infections in animals or directly link them to human infections using genomic data. In the present study, we describe the first cases of natural SARS-CoV-2 infection in tigers and lions in the United States and provide epidemiological and genetic evidence for human-to-animal transmission of the virus. Our data show that tigers and lions were infected with different genotypes of SARS-CoV-2, indicating two independent transmission events to the animals. Importantly, infected animals shed infectious virus in respiratory secretions and feces. A better understanding of the susceptibility of animal species to SARS-CoV-2 may help to elucidate transmission mechanisms and identify potential reservoirs and sources of infection that are important in both animal and human health.

Funder

USDA | National Institute of Food and Agriculture

U.S. Department of Agriculture

HHS | U.S. Food and Drug Administration

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02220-20

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