A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model-Reference-Cited by-同舟云学术

A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Strohmeier Shirin¹²,Amanat Fatima¹³,Zhu Xueyong⁴,McMahon Meagan¹^ORCID,Deming Meagan E.⁵,Pasetti Marcela F.⁵,Neuzil Kathleen M.⁵,Wilson Ian A.⁴⁶,Krammer Florian¹⁷^ORCID

Affiliation:

1. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

2. Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria

3. Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA

4. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA

5. Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA

6. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA

7. Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

Influenza virus infections remain a high risk to human health, causing up to 650,000 deaths worldwide every year, with an enormous burden on the health care system. Since currently available seasonal vaccines are only partially effective and often mismatched to the circulating strains, a broader protective influenza virus vaccine is needed.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of General Medical Sciences

U.S. Department of Energy

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02241-21

Reference65 articles.