Iminosugar Glucosidase Inhibitors Reduce Hepatic Inflammation in Hepatitis A Virus-Infected Ifnar1 −/− Mice

Author:

Misumi Ichiro1,Li Zhucui2,Sun Lu3,Das Anshuman3,Shiota Tomoyuki3,Cullen John4,Zhang Qibin25,Whitmire Jason K.136,Lemon Stanley M.367ORCID

Affiliation:

1. Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. UNCG Center for Translational Biomedical Research, North Carolina Research Campus, Kannapolis, North Carolina, USA

3. Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

4. College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

5. Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina, USA

6. Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

7. Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

Hepatitis A virus (HAV) is a common cause of viral hepatitis. Iminosugar compounds block its replication in cultured cells by inhibiting the synthesis of gangliosides required for HAV cell entry but have not been tested for their ability to prevent or treat hepatitis A in vivo .

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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