Aliidiomarina shirensis as Possible Source of the Integron- and Plasmid-Mediated Fosfomycin Resistance Gene fosC2

Author:

Ortiz de la Rosa Jose-Manuel1,Nordmann Patrice1234ORCID,Zong Zhiyong5678,Poirel Laurent123ORCID

Affiliation:

1. Emerging Antibiotic Resistance, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland

2. INSERM European Unit (LEA), (IAME, Paris) University of Fribourg, Fribourg, Switzerland

3. Institute for Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

4. Service of Hospital Preventive Medicine, Lausanne University Hospital and University Hospital, Lausanne, Switzerland

5. Center for Pathogen Research, West China Hospital, Sichuan University, Chengdu, Sichuan, China

6. Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, China

7. Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, Sichuan, China

8. Department of Infection Control, West China Hospital, Sichuan University, Chengdu, Sichuan, China

Abstract

In-silico analysis and cloning experiments identified a fosC2- like fosfomycin resistance gene in the chromosome of Aliidiomarina shirensis , with our data suggesting that this bacterium might be added to the list of species identified as reservoirs of fos -like genes that were subsequently acquired by other Gram-negative species. Indeed, the fosC2 gene was identified as acquired in Providencia huaxinensis and Aeromonas hydrophila isolates, with this gene being located in class 1 integron structures in the latter cases.

Funder

University of Fribourg

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat;Frontiers in Cellular and Infection Microbiology;2023-07-04

2. Wildlife and Antibiotic Resistance;Frontiers in Cellular and Infection Microbiology;2022-05-11

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