Plasmacytoid Dendritic Cell-Derived Type I Interferon Is Involved in Helicobacter pylori Infection-Induced Differentiation of Schlafen 4-Expressing Myeloid-Derived Suppressor Cells-Reference-Cited by-同舟云学术

Plasmacytoid Dendritic Cell-Derived Type I Interferon Is Involved in Helicobacter pylori Infection-Induced Differentiation of Schlafen 4-Expressing Myeloid-Derived Suppressor Cells

Published:2021-10-15 Issue:11 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Xiang Xiaodan¹,Wu Yaping¹,Li Hongwei¹,Li Cun¹,Yan Lu¹,Li Qian¹^ORCID

Affiliation:

1. Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China

Abstract

During chronic infection with Helicobacter pylori , Schlafen 4-expressing myeloid-derived suppressor cells (SLFN4 + MDSCs) create a microenvironment favoring intestinal metaplasia and neoplastic transformation. SLFN4 can be induced by alpha interferon (IFN-α), which is mainly secreted from plasmacytoid dendritic cells (pDCs).

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00407-21

Reference18 articles.

1. Molecular Alterations in Gastric Intestinal Metaplasia

2. The eradication of Helicobacter pylori to prevent gastric cancer: a critical appraisal

3. Gastric Cancer