Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis-Reference-Cited by-同舟云学术

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis

Published:2019-08 Issue:8 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Birnie Emma¹^ORCID,Weehuizen Tassili A. F.¹,Lankelma Jacqueline M.¹,de Jong Hanna K.¹,Koh Gavin C. K. W.¹²,van Lieshout Miriam H. P.¹,Roelofs Joris J. T. H.³,Budding Andries E.⁴,de Vos Alex F.¹,van der Poll Tom¹⁵,Wiersinga W. Joost¹⁵

Affiliation:

1. Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

2. Department of Medicine, University of Cambridge, Cambridge, United Kingdom

3. Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

4. Department of Medical Microbiology and Infection Control, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands

5. Department of Medicine, Division of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

Abstract

The Gram-negative intracellular pathogen Burkholderia pseudomallei is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is essential for an appropriate immune response during pathogen invasion. In patients with melioidosis, TLR5 is the most abundantly expressed TLR, and a hypofunctional TLR5 variant has been associated with improved survival.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

ZonMw

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00409-18

Reference59 articles.

1. Melioidosis: Evolving Concepts in Epidemiology, Pathogenesis, and Treatment

2. Melioidosis

3. Melioidosis

4. Possession, use, and transfer of select agents and toxins; biennial review. Final rule;Centers for Disease Control and Prevention, Department of Health and Human Services;Fed Regist,2012

5. Clinical Features and Epidemiology of Melioidosis Pneumonia: Results From a 21-Year Study and Review of the Literature

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