Streptococcus oralis subsp. dentisani Produces Monolateral Serine-Rich Repeat Protein Fibrils, One of Which Contributes to Saliva Binding via Sialic Acid-Reference-Cited by-同舟云学术

Streptococcus oralis subsp. dentisani Produces Monolateral Serine-Rich Repeat Protein Fibrils, One of Which Contributes to Saliva Binding via Sialic Acid

Published:2019-10 Issue:10 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ronis Allen¹,Brockman Kenneth¹,Singh Anirudh K.¹,Gaytán Meztlli O.¹,Wong Alexander¹²,McGrath Sean³,Owen C. David⁴,Magrini Vincent³⁵,Wilson Richard K.³⁵,van der Linden Mark⁶,King Samantha J.¹⁵^ORCID

Affiliation:

1. Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA

2. Medical Student Research Program, The Ohio State University College of Medicine, The Ohio State University, Columbus, Ohio, USA

3. Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA

4. Diamond Light Source, Didcot, Oxfordshire, United Kingdom

5. Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA

6. Institute of Medical Microbiology, German National Reference Center for Streptococci, University Hospital (RWTH), Aachen, Germany

Abstract

Our studies reveal that the oral colonizer and cause of infective endocarditis Streptococcus oralis subsp. dentisani displays a striking monolateral distribution of surface fibrils. Furthermore, our data suggest that these fibrils impact the structure of adherent bacterial chains.

Funder

American Heart Association

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00406-19

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