Synergy between Circular Bacteriocin AS-48 and Ethambutol against Mycobacterium tuberculosis

Author:

Aguilar-Pérez Clara123,Gracia Begoña1234,Rodrigues Liliana12345,Vitoria Asunción12346,Cebrián Rubén7,Deboosère Nathalie8,Song Ok-ryul8,Brodin Priscille8,Maqueda Mercedes7,Aínsa José A.1234

Affiliation:

1. Departamento de Microbiología, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain

2. Instituto de Biocomputacion y Fisica de Sistemas Complejos, Universidad de Zaragoza, Zaragoza, Spain

3. Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain

4. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain

5. Fundación Agencia Aragonesa para la Investigación y el Desarrollo, Zaragoza, Spain

6. Grupo de Estudio de Infecciones por Micobacterias de la SEIMC, Madrid, Spain

7. Departamento de Microbiología, Facultad de Ciencias, Universidad de Granada, Granada, Spain

8. Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019, UMR 8204, Center for Infection and Immunity of Lille, Lille, France

Abstract

The increasing incidence of multidrug-resistant Mycobacterium tuberculosis strains and the very few drugs available for treatment are promoting the discovery and development of new molecules that could help in the control of this disease. Bacteriocin AS-48 is an antibacterial peptide produced by Enterococcus faecalis and is active against several Gram-positive bacteria.

Funder

European Commission

European Molecular Biology Organization

Agence Nationale de la Recherche

Ministerio de Economía y Competitividad

EC | European Regional Development Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference44 articles.

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