Deciphering Heteroresistance to Colistin in a Klebsiella pneumoniae Isolate from Marseille, France-Reference-Cited by-同舟云学术

Deciphering Heteroresistance to Colistin in a Klebsiella pneumoniae Isolate from Marseille, France

Published:2017-06 Issue:6 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bardet Lucie¹,Baron Sophie¹,Leangapichart Thongpan¹,Okdah Liliane¹,Diene Seydina M.¹,Rolain Jean-Marc¹

Affiliation:

1. URMITE, Faculté de Médecine et de Pharmacie, Aix Marseille Université, UM63, CNRS 7278, IRD 198, INSERM 1095, IHU-Méditerranée Infection, Marseille, France

Abstract

ABSTRACT Here, we report the description of a colistin-heteroresistant Klebsiella pneumoniae isolate fortuitously isolated from the stool sample of a patient with suspicion of tuberculosis in a public hospital of Marseille, France. In the colistin-resistant subpopulation, a mutation in the mgrB gene leading to a premature stop codon was found, and the hypermucoviscous phenotype was lost. Susceptibility to other antibiotics remained unchanged. To our knowledge, this is the first identification of such a colistin-heteroresistant Klebsiella pneumoniae isolate in France.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00356-17

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