Inflammatory Cytokines Inhibit Kaposi's Sarcoma-Associated Herpesvirus Lytic Gene Transcription in In Vitro-Infected Endothelial Cells-Reference-Cited by-同舟云学术

Inflammatory Cytokines Inhibit Kaposi's Sarcoma-Associated Herpesvirus Lytic Gene Transcription in In Vitro-Infected Endothelial Cells

Published:2004-03 Issue:5 Volume:78 Page:2591-2596
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Milligan Steven¹,Robinson Mairi¹,O'Donnell Elizabeth¹,Blackbourn David J.¹

Affiliation:

1. Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, United Kingdom

Abstract

ABSTRACT The response of Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) to inflammatory cytokine treatment of experimentally infected endothelial cells was investigated. The cytokines inhibited spontaneous KSHV lytic gene expression but not the level of infection. The data suggest that if inflammatory cytokines present in KS lesions contribute to KSHV pathogenesis, they do so in part by promoting latent KSHV infection of the endothelial cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.5.2591-2596.2004

Reference38 articles.

1. Blackbourn D. J. L. F. Chuang S. Sutjipto K. F. Killam Jr. P. M. McCready R. H. Doi Y. Li and R. Y. Chuang. 1992. Detection of simian immunodeficiency virus RNA from infected rhesus macaques by the polymerase chain reaction. J. Virol. Methods 37: 109-117.

2. Blackbourn, D. J., S. Fujimura, T. Kutzkey, and J. A. Levy. 2000. Induction of HHV-8 gene expression by recombinant interferon-gamma. AIDS14:12-13.

3. Boshoff, C., T. F. Schulz, M. M. Kennedy, A. K. Graham, C. Fisher, A. Thomas, J. O. McGee, R. A. Weiss, and J. J. O'Leary. 1995. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat. Med.1:1274-1278.

4. A New Primary Effusion Lymphoma-Derived Cell Line Yields a Highly Infectious Kaposi's Sarcoma Herpesvirus-Containing Supernatant

5. Chang, J., R. Renne, D. Dittmer, and D. Ganem. 2000. Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication. Virology266:17-25.

Cited by 29 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Demographic characteristics, treatment, and outcome of patients with Kaposi sarcoma: Ten‐year follow‐up results of a single center;Journal of Cosmetic Dermatology;2021-09-15

2. Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation;Cell Reports;2020-10

3. Kaposi sarcoma misdiagnosed as granuloma annulare: A case of mistaken identity;Journal of Cutaneous Pathology;2020-09-28

4. Pathogenic Th1 responses in CHIKV‐induced inflammation and their modulation upon Plasmodium parasites co‐infection;Immunological Reviews;2019-11-26

5. Cell Type-Specific Interferon-γ-mediated Antagonism of KSHV Lytic Replication;Scientific Reports;2019-02-20