Role of Indoleamine-2,3-Dioxygenase in Alpha/Beta and Gamma Interferon-Mediated Antiviral Effects against Herpes Simplex Virus Infections-Reference-Cited by-同舟云学术

Role of Indoleamine-2,3-Dioxygenase in Alpha/Beta and Gamma Interferon-Mediated Antiviral Effects against Herpes Simplex Virus Infections

Published:2004-03 Issue:5 Volume:78 Page:2632-2636
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Adams O.¹,Besken K.²,Oberdörfer C.²,MacKenzie C. R.²,Takikawa O.³,Däubener W.²

Affiliation:

1. Institut für Virologie

2. Institut für Medizinische Mikrobiologie, Heinrich-Heine-Universität, D-40225 Dusseldorf, Germany

3. Department of Cell Pharmacology, Hokkaido University, Sapporo 060-8638, Japan

Abstract

ABSTRACT Gamma interferon (IFN-γ)-mediated indoleamine-2,3-dioxygenase (IDO) activity in human astrocytoma cells and in native astrocytes was found to be responsible for the inhibition of herpes simplex virus replication. The effect is abolished in the presence of excess amounts of l -tryptophan. Both IFN-α and IFN-β restricted herpes simplex virus replication in both cell types, but (in contrast to the results seen with IFN-γ) the addition of an excess amount of l -tryptophan did not inhibit the induced antiviral effect.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.5.2632-2636.2004

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