Role of Indoleamine-2,3-Dioxygenase in Alpha/Beta and Gamma Interferon-Mediated Antiviral Effects against Herpes Simplex Virus Infections-Reference-Cited by-同舟云学术

Role of Indoleamine-2,3-Dioxygenase in Alpha/Beta and Gamma Interferon-Mediated Antiviral Effects against Herpes Simplex Virus Infections

Published:2004-03 Issue:5 Volume:78 Page:2632-2636
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Adams O.¹,Besken K.²,Oberdörfer C.²,MacKenzie C. R.²,Takikawa O.³,Däubener W.²

Affiliation:

1. Institut für Virologie

2. Institut für Medizinische Mikrobiologie, Heinrich-Heine-Universität, D-40225 Dusseldorf, Germany

3. Department of Cell Pharmacology, Hokkaido University, Sapporo 060-8638, Japan

Abstract

ABSTRACT Gamma interferon (IFN-γ)-mediated indoleamine-2,3-dioxygenase (IDO) activity in human astrocytoma cells and in native astrocytes was found to be responsible for the inhibition of herpes simplex virus replication. The effect is abolished in the presence of excess amounts of l -tryptophan. Both IFN-α and IFN-β restricted herpes simplex virus replication in both cell types, but (in contrast to the results seen with IFN-γ) the addition of an excess amount of l -tryptophan did not inhibit the induced antiviral effect.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.5.2632-2636.2004

Reference44 articles.

1. Becker, Y. 2002. Herpes simplex virus evolved to use the human defense mechanisms to establish a lifelong infection in neurons—a review and hypothesis. Virus Genes24:187-196.

2. Bilzer, T., D. Stavrou, E. Dahme, E. Keiditsch, K. F. Burrig, A. P. Anzil, and W. Wechsler. 1991. Morphological, immunocytochemical and growth characteristics of three human glioblastomas established in vitro. Virchows Arch. A Pathol. Anat. Histopathol.418:281-293.

3. Bodaghi, B., O. Goureau, D. Zipeto, L. Laurent, J. L. Virelizier, and S. Michelson. 1999. Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells. J. Immunol.162:957-964.

4. Bogdan, C., M. Rollinghoff, and A. Diefenbach. 2000. The role of nitric oxide in innate immunity. Immunol. Rev.173:17-26.

5. Bukrinsky, M., H. Schmidtmayerova, G. Zybarth, L. Dubrovsky, B. Sherry, and G. Enikolopov. 1996. A critical role of nitric oxide in human immunodeficiency virus type 1-induced hyperresponsiveness of cultured monocytes. Mol. Med.2:460-468.

Cited by 97 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The kynurenine pathway of tryptophan metabolism: a neglected therapeutic target of COVID-19 pathophysiology and immunotherapy;Bioscience Reports;2023-08

2. Differential Expression Patterns of Indoleamine 2,3-Dioxygenase 1 and Other Tryptophan and Arginine Catabolic Pathway Genes in Dengue Correlate with Clinical Severity-Pilot Study Results;Viral Immunology;2023-05-01

3. IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement;Cells;2022-07-19

4. Unbalanced IDO1/IDO2 Endothelial Expression and Skewed Keynurenine Pathway in the Pathogenesis of COVID-19 and Post-COVID-19 Pneumonia;Biomedicines;2022-06-06

5. Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection;Pathogens;2022-04-07