Exploitation of a Bacterium-Encoded Lytic Transglycosylase by a Human Oral Lytic Phage To Facilitate Infection-Reference-Cited by-同舟云学术

Exploitation of a Bacterium-Encoded Lytic Transglycosylase by a Human Oral Lytic Phage To Facilitate Infection

Published:2022-09-14 Issue:17 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Cen Lujia¹,Chang Yunjie²,Bedree Joseph K.¹,Ma Yansong³,Zhong Qiu⁴,Utter Daniel R.⁵,Dong Pu-Ting¹,Lux Renate⁶,Bor Batbileg¹⁷^ORCID,Liu Jun²^ORCID,McLean Jeffrey S.⁸^ORCID,Le Shuai⁴^ORCID,He Xuesong¹⁷^ORCID

Affiliation:

1. Department of Microbiology, The Forsyth Institute, Cambridge, Massachusetts, USA

2. Microbial Sciences Institute, Yale University, New Haven, Connecticut, USA

3. Capital University of Medicine, Beijing, China

4. Department of Microbiology, Army Medical University, Chongqing, China

5. Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, California, USA

6. Section of Biosystems and Function, UCLA School of Dentistry, Los Angeles, California, USA

7. Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA

8. Department of Periodontics, University of Washington, Seattle, Washington, USA

Abstract

The evidence for the presence of a diverse and abundant phage population in the host-associated oral microbiome came largely from metagenomic analysis or the observation of virus-like particles within saliva/plaque samples, while the isolation of oral phage and investigation of their interaction with bacterial hosts are limited. Here, we report the isolation of LC001, the first lytic phage targeting oral Schaalia odontolytica .

Funder

HHS | NIH | National Institute of Dental and Craniofacial Research

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01063-22

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