SARS-CoV-2 Nonstructural Protein 1 Inhibits the Interferon Response by Causing Depletion of Key Host Signaling Factors-Reference-Cited by-同舟云学术

SARS-CoV-2 Nonstructural Protein 1 Inhibits the Interferon Response by Causing Depletion of Key Host Signaling Factors

Published:2021-06-10 Issue:13 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kumar Anil¹^ORCID,Ishida Ray²,Strilets Tania²,Cole Jamie¹,Lopez-Orozco Joaquin³,Fayad Nawell¹,Felix-Lopez Alberto²,Elaish Mohamed¹,Evseev Danyel⁴,Magor Katharine E.⁴,Mahal Lara K.⁵,Nagata Les P.⁶,Evans David H.²⁷^ORCID,Hobman Tom C.¹²⁷

Affiliation:

1. Department of Cell Biology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada

2. Department of Medical Microbiology & Immunology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada

3. High Content Analysis Core, University of Alberta, Edmonton, Canada

4. Department of Biological Sciences, University of Alberta, Edmonton, Canada

5. Department of Chemistry, University of Alberta, Edmonton, Canada

6. Defence Research and Development Canada, Suffield Research Centre, Medicine Hat, Canada

7. Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Canada

Abstract

SARS-CoV-2 is the causative agent of COVID-19, a serious disease that can have a myriad of symptoms from loss of taste and smell to pneumonia and hypercoagulation. The rapid spread of SARS-CoV-2 can be attributed in part to asymptomatic transmission, where infected individuals shed large amounts of virus before the onset of disease.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

U of A | Li Ka Shing Institute of Virology, University of Alberta

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00266-21

Reference32 articles.

1. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

2. A Novel Coronavirus from Patients with Pneumonia in China, 2019