Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques-Reference-Cited by-同舟云学术

Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Hasenkrug Kim J.¹^ORCID,Feldmann Friederike²,Myers Lara¹,Santiago Mario L.³,Guo Kejun³,Barrett Bradley S.³,Mickens Kaylee L.³,Carmody Aaron⁴,Okumura Atsushi⁵^ORCID,Rao Deepashri¹,Collins Madison M.¹,Messer Ronald J.¹,Lovaglio Jamie²,Shaia Carl²,Rosenke Rebecca²,van Doremalen Neeltje⁵,Clancy Chad²,Saturday Greg²,Hanley Patrick²,Smith Brian J.²,Meade-White Kimberly⁵,Shupert W. Lesley⁵,Hawman David W.⁵,Feldmann Heinz⁵^ORCID

Affiliation:

1. Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

2. Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

3. Departments of Medicine, Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA

4. Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

5. Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

Abstract

Patients with severe COVID-19 often have decreased numbers of T cells, a cell type important in fighting most viral infections. However, it is not known whether the loss of T cells contributes to severe COVID-19 or is a consequence of it.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Division of Infectious Diseases, University of Colorado

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01503-21

Reference40 articles.

1. Dynamics of CD4 T Cell and Antibody Responses in COVID-19 Patients With Different Disease Severity

2. T cell responses in patients with COVID-19