Performance of Xpert MTB/RIF, Xpert Ultra, and Abbott RealTi m e MTB for Diagnosis of Pulmonary Tuberculosis in a High-HIV-Burden Setting-Reference-Cited by-同舟云学术

Performance of Xpert MTB/RIF, Xpert Ultra, and Abbott RealTi m e MTB for Diagnosis of Pulmonary Tuberculosis in a High-HIV-Burden Setting

Published:2018-12 Issue:12 Volume:56 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Berhanu Rebecca H.¹²^ORCID,David Anura³,da Silva Pedro³,Shearer Kate¹⁴,Sanne Ian¹²,Stevens Wendy³⁵,Scott Lesley⁵

Affiliation:

1. Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

2. Clinical HIV Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

3. National Priority Program, National Health Laboratory Service, Johannesburg, South Africa

4. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

5. Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Abstract

More sensitive tests are needed for the diagnosis of smear-negative and HIV-associated tuberculosis. This study compares the sensitivities and specificities of three molecular tests, namely, the Xpert MTB/RIF test, the Xpert Ultra (Ultra), and RealTi m e MTB (RT-MTB), in a high HIV prevalence setting.

Funder

National Institute of Health Fogarty International Center

UK-South Africa Newtown Fund

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00560-18

Reference22 articles.

1. Rapid Molecular Detection of Tuberculosis and Rifampin Resistance

2. Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults