Affiliation:
1. Children's Hospital, University of Munich, Munich, Germany
Abstract
An in vitro system was developed to test the phagocytic activity of human macrophages grown from blood monocytes in the presence of the antibiotics ampicillin, tetracycline, and chloramphenicol.
3
H-labeled
Listeria monocytogenes
served as test organism. Subinhibitory amounts of the antibiotics enhanced the phagocytic activity significantly (
P
< 0.025). Macrophages pretreated with the drugs in identical concentrations showed the same phagocytic activity as control cells in the absence of the drugs. Because the drug concentrations used were similar to those that may be attained in man at certain places of inflammation, enhanced phagocytosis in the presence of antibiotics may have clinical significance.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference20 articles.
1. Effect of dihydrostreptomvcin on phagocytosis of mouse-peritoneal macrophages in vitro;Adam D.;Infect. Immunity,1972
2. Die Rolle des Wirts bei der klinischen Wirkung der antibakteriellen Chemotherapie;Adam D.;Med. Klin.,1971
3. Studies on the influence of host defense mechanisms on the antimicrobial effect of chemotherapeutic agents. Effect of antibiotics on phagocytosis of mouse peritoneal macrophages in vitro;Adam D.;Arztliche Forschung,1971
4. Contribution of serum and cellular factors in host defense reactions. I. Serum factors in host resistance;Austen K. F.;N. Engl. J. Med.,1963
5. The isolation and selected properties of blood monocytes;Bennet W. E.;J. Exp. Med.,1966
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