Leukocytosis-Promoting Factor of Bordetella pertussis III. Its Identity with Protective Antigen-Reference-Cited by-同舟云学术

Leukocytosis-Promoting Factor of Bordetella pertussis III. Its Identity with Protective Antigen

Published:1974-05 Issue:5 Volume:9 Page:801-810
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Sato Yuji¹,Arai Hideo¹,Suzuki Kenji¹

Affiliation:

1. The First Department of Bacteriology and Department of Chemistry, National Institute of Health, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

Abstract

Leukocytosis-promoting factor (LPF) was purified from the supernatant of a 5-day liquid culture of Bordetella pertussis strains Tohama and no. 134. The preparations appeared to be filamentous molecules (2 by 40 nm) and contained histamine-sensitizing and hemagglutinin activities in addition to leukocytosis-promoting activity. Active protection tests in mice demonstrated strong protective activities of 80 international protective units per mg of protein in LPF preparations of each strain toxoided by mild Formalin treatment. Passive protection tests in mice with anti-LPF sera indicated that anti-LPF is one of the protective antibodies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.9.5.801-810.1974

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