Affiliation:
1. Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, California 92093-0613
Abstract
ABSTRACT
LIM domain-containing proteins play critical roles in vertebrate development and cellular differentiation. Recently, four members of the four and one-half LIM protein (FHL) family have been identified and cloned. One of these, FHL2, is expressed in a restricted manner in the cardiovascular system throughout development into adulthood, suggesting that
FHL2
may play an important role in cardiovascular development and function. Here we describe the generation and analysis of mice carrying a null mutation of the
FHL2
gene.
FHL2
-deficient mice are viable and maintain normal cardiac function both before and after acute mechanical stress induced by aortic constriction. These data suggest that
FHL2
is not essential for cardiac development and function.
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
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