Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues-Reference-Cited by-同舟云学术

Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues

Published:1999-05 Issue:5 Volume:43 Page:1307-1309
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Brunner Martin¹,Hollenstein Ursula²,Delacher Simon¹,Jäger Dorothea¹,Schmid Rainer³,Lackner Edith¹,Georgopoulos Apostoulos²,Eichler Hans Georg¹,Müller Markus¹

Affiliation:

1. Department of Clinical Pharmacology,1

2. Department of Internal Medicine I, Division of Infectious Diseases and Chemotherapy,2 and Department of

3. Clinical and Laboratory Investigation,3University of Vienna Medical School, Vienna, Austria

Abstract

ABSTRACT Interstitial ciprofloxacin concentrations in soft tissues were measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum drug concentrations; the interstitium-to-serum concentration ratios ranged from 0.55 to 0.73. An in vitro simulation based on interstitial pharmacokinetics showed a substantially lower antimicrobial activity than did the simulation based on serum pharmacokinetics. Thus, ciprofloxacin concentrations at the site of effect may be subinhibitory although effective concentrations are attained in serum.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.5.1307

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