Affiliation:
1. Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University , Suzhou, Jiangsu, China
2. Department of Clinical Laboratory, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine , Zhangjiagang, Jiangsu, China
Abstract
ABSTRACT
Bacteria frequently interfere with the post-translational modifications of host cells to facilitate their survival and growth after invasion. SUMOylation, a reversible post-translational modification process, plays an important role in biological life activities. In addition to being critical to host cell metabolism and survival, SUMOylation also regulates gene expression and cell signal transmission. Moreover, SUMOylation in eukaryotic cells can be used by a variety of bacterial pathogens to advance bacterial invasion. In this minireview, we focused on the role and mechanism of host SUMOylation in the pathogenesis of six important clinical bacterial pathogens (
Listeria monocytogenes
,
Shigella flexneri
,
Salmonella
Typhimurium
, Klebsiella pneumoniae
,
Staphylococcus aureus
, and
Escherichia coli
). Taken together, this review provided new insights for understanding the unique pathogen-host interaction based on host SUMOylation and provided a novel perspective on the development of new strategies to combat bacterial infections in the future.
Funder
MOST | National Natural Science Foundation of China
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
1 articles.
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