Affiliation:
1. Departments of Surgery and Medicine, University of Louisville School of Medicine, and the Price Institute of Surgical Research, Health Sciences Center, Louisville, Kentucky 40201
Abstract
The time rates of binding of three antibiotics of similar chemical structure, each with differing degrees of protein binding, were determined. Cephaloridine, which is 10% bound by serum proteins, was bound at a more rapid rate than cephalothin, which is 40% bound by serum protein. Cefazolin, bound 80%, required for longest time period for maximum binding to occur. The rate of protein binding appears directly related to the total percentage bound. The data from this study indicate that prolonged rates of binding of highly protein-bound drugs may influence pharmacological studies.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference11 articles.
1. Laboratory and clinical experience with cephalexin;Kind A. C.;Antimicrob. Ag. Chemother.,1969
2. Cefazolin, a new semisynthetic cephalosporin antibiotic. VI. Excretion and metabolism of cefazolin"C in rats after intramuscular administration;Kozatani J.;J. Antibiot. (Tokyo),1972
3. The binding of drugs by plasma proteins;Meyer M. C.;J. Pharm. Sci.,1968
4. Cefazolin, a new semisynthetic cephalosporin antibiotic. H. In vitro and in vivo antimicrobial activity;Nishida M.;J. Antibiot. (Tokyo),1970
5. In vitro and in vivo evaluation of cefazolin, a new cephalosporin C derivative;Nishida M.;Antimicrob. Ag. Chemother.,1970
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献