Microarray Analysis and Functional Characterization of the Nitrosative Stress Response in Nonmucoid and Mucoid Pseudomonas aeruginosa

Author:

Firoved Aaron M.1,Wood Simon R.23,Ornatowski Wojciech1,Deretic Vojo1,Timmins Graham S.2

Affiliation:

1. Department of Molecular Genetics and Microbiology

2. College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131

3. Division of Oral Biology, Leeds Dental Institute, University of Leeds, Leeds, United Kingdom

Abstract

ABSTRACT The type strain of Pseudomonas aeruginosa , PAO1, showed great upregulation of many nitrosative defense genes upon treatment with S- nitrosoglutathione, while the mucoid strain PAO578II showed no further upregulation above its constitutive upregulation of nor and fhp . NO · consumption however, showed that both strains mount functional, protein synthesis-dependent NO · -consumptive responses.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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