Highlighting the Unique Roles of Radical <i>S</i> -Adenosylmethionine Enzymes in Methanogenic Archaea-Reference-Cited by-同舟云学术

Highlighting the Unique Roles of Radical S -Adenosylmethionine Enzymes in Methanogenic Archaea

Published:2022-08-16 Issue:8 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Boswinkle Kaleb¹,McKinney Justin¹,Allen Kylie D.¹^ORCID

Affiliation:

1. Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA

Abstract

Radical S -adenosylmethionine (SAM) enzymes catalyze an impressive variety of difficult biochemical reactions in various pathways across all domains of life. These metalloenzymes employ a reduced [4Fe-4S] cluster and SAM to generate a highly reactive 5′-deoxyadenosyl radical that is capable of initiating catalysis on otherwise unreactive substrates.

Funder

National Science Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00197-22

Reference131 articles.

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3. Radical S-Adenosylmethionine Enzymes

4. Coordination of Adenosylmethionine to a Unique Iron Site of the [4Fe-4S] of Pyruvate Formate-Lyase Activating Enzyme: A Mössbauer Spectroscopic Study

5. Radical SAM enzymes: surprises along the path to understanding mechanism

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