Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis

Published:2005-02 Issue:2 Volume:73 Page:1196-1203
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Sambandamurthy Vasan K.¹²,Derrick Steven C.³,Jalapathy Kripa V.²,Chen Bing¹²,Russell Robert G.⁴,Morris Sheldon L.³,Jacobs William R.¹²

Affiliation:

1. Howard Hughes Medical Institute

2. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York

3. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland

4. Department of Pathology, Lombardi Cancer Center, Georgetown University, Washington, D.C.

Abstract

ABSTRACT We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The Δ lysA Δ panCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.2.1196-1203.2005

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