Comparison of Serum Hepatitis B Virus RNA Levels and Quasispecies Evolution Patterns between Entecavir and Pegylated-Interferon Mono-treatment in Chronic Hepatitis B Patients-Reference-Cited by-同舟云学术

Comparison of Serum Hepatitis B Virus RNA Levels and Quasispecies Evolution Patterns between Entecavir and Pegylated-Interferon Mono-treatment in Chronic Hepatitis B Patients

Published:2020-08-24 Issue:9 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Yu Xiao-qi¹,Wang Ming-jie¹,Yu De-min¹,Chen Pei-zhan²,Zhu Ming-yu³,Huang Wei¹,Han Yue¹,Gong Qi-ming⁴,Zhang Xin-xin¹²

Affiliation:

1. Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

2. Clinical Research Center, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, China

3. Department of Gastroenterology & Hepatology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, China

4. Department of Infectious Diseases, Institute of Infectious & Respiratory Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Abstract

Hepatitis B virus (HBV) RNA may independently predict virological and serological response. This study aimed to compare dynamic changes in serum HBV RNA levels and HBV quasispecies evolution patterns between entecavir and pegylated-interferon mono-treatment in chronic hepatitis B patients and to determine the clinical significance during treatment. TaqMan real-time PCR was used for quantitative analysis. HBV RNA levels were retrospectively determined in serial serum samples from 178 chronic hepatitis B patients who received either entecavir or pegylated-interferon treatment.

Funder

National Science and Technology Major Project

Shanghai International Collaboration Project

National Natural Science Foundation of China

Shanghai Shen Kang Hospital Development Center

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00075-20

Reference34 articles.