Affiliation:
1. Division
of Infectious Disease, Department of Internal
Medicine
2. Clinical Research
Institute, College of Medicine, Catholic
University of Korea, Seoul, Korea
Abstract
ABSTRACT
The
effects of moxifloxacin, a new methoxyfluoroquinolone, on the
production of proinflammatory cytokines from human peripheral blood
mononuclear cells (PBMCs) were evaluated. Moxifloxacin inhibited the
production of tumor necrosis factor alpha (TNF-α) and/or
interleukin-6 (IL-6) by PBMCs stimulated with lipopolysaccharide (LPS),
lipoteichoic acid (LTA), and heat-killed bacteria in a
concentration-dependent manner without cytotoxic effects. The addition
of moxifloxacin reduced the population of cells positive for CD-14
and TNF-α and for CD-14 and IL-6 among the LPS- or
LTA-stimulated PBMCs. By Western blot analysis, moxifloxacin
pretreatment reduced the degradation of IκBα in
LPS-stimulated PBMCs. In conclusion, moxifloxacin could interfere with
NF-κB activation by inhibiting the degradation of
IκBα and reduce the levels of production of
proinflammatory
cytokines.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
37 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献